Plexin A3 anticorps (Extracellular, N-Term)

N° du produit ABIN7885234

L’anticorps anti-Plexin A3 Polyclonal Lapin est utilisé pour la détection de Plexin A3 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC, WB, FACS, IF et LCI.

Aperçu rapide pour Plexin A3 anticorps (Extracellular, N-Term) (ABIN7885234)

Antigène: Plexin A3 (PLXNA3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin A3 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Plexin A3 anticorps

Épitope: AA 440-453, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Plexin-A3

Homologie: Rat - identical, human - 12,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KVRVDGSQDAQLYE, corresponding to amino acid residues 440-453 of mouse PLXNA3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236268)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Plexin A3

Antigène: Plexin A3 (PLXNA3)

Autre désignation: PLXNA3

Sujet:

Synonyms: PLXNA3, PLXN3, Semaphorin receptor SEX

Description: Plexins are type 1 transmembrane (TM) receptors acting as key regulatory proteins in a wide variety of developmental, regenerative and pathological processes. They are involved in guidance and motility of vascular, lymphatic vessel, and neuron growth, and in cancer metastasis.Plexin family includes 9 proteins: Plexin-A1-4, -B1-3, -C1 and -D1. Class A Plexins interact with the secreted class 3 Semaphorins, and require Neuropilins (nrps) as co-receptors.Plexin protein signaling results in cytosolic GTPase-activating protein activity including direct interactions with Rho GTPases and transient/catalytic interactions with Ras GTPases1,2.Plexin structure consists of an extracellular semaphorin domain, three Plexin-Semaphorin-Integrin (PSI) domains, and three immunoglobulin, Plexin, and transcription factor (IPT) domains. In addition, a single-spanning transmembrane domain, and a cytosolic region (CYTO) homologous with Ras GTPase-activating proteins (GAPs)2. The transmembrane region of Plexin-A3 is characterized by poly-glycine usually used for close helix-helix packing and aromatic residues that distort helix conformation and association. Plexin-A family members only have 22 residues spanning the membrane1.Mutations in Plexins have been reported in melanoma, lung, breast, pancreatic, and prostate cancers, strongly suggesting that their signaling may play a role in cancer development. Plexins are widely expressed in the nervous system and in the developing cerebral cortex2.

ID gène: 18846

UniProt: P70208

Pathways: Regulation of Cell Size