Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) anticorps

N° du produit ABIN7885365

Cet anticorps Lapin Polyclonal détecte spécifiquement Regulating Synaptic Membrane Exocytosis 1 dans WB. Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) anticorps (ABIN7885365)

Antigène: Regulating Synaptic Membrane Exocytosis 1 (RIMS1)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit

Épitope: AA 1039-1054, Intracellular

Fonction: A Rabbit Polyclonal Antibody to RIM1

Homologie: human - 14,16 amino acid residues identical,Mouse - 15

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RAKRGRSAESLHMTSE, corresponding to amino acid residues 1039-1054 of rat RIM1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236714)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détail du antigène

Antigène: Regulating Synaptic Membrane Exocytosis 1 (RIMS1)

Autre désignation: Regulating synaptic membrane exocytosis 1

Sujet:

Synonyms: Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1

Description: RIM1 is a member of the RIM superfamily of proteins (Rim1-4). These genes express seven known RIM isoforms: RIM1α, 1β, RIM2α, 2β, 2γ, and RIM3γ and RIM4γ which serve as scaffolding proteins in presynaptic nerve terminals by interacting with several other protein components localized at the active zone, including Munc13, ELKS (or CAST), liprins and voltage-gated Ca2+ channels (VGCCs). RIM1 directly binds to the C-terminal regions of the α1 subunit of N- and P/Q-type calcium channels, and can also interact with the β auxiliary subunit of P/Q-type calcium channels1-3.RIM proteins were found to be required for normal Ca2+ triggering of exocytosis. This interaction with Ca2+ channel significantly slows channel inactivation resulting in increased Ca2+ influx during action potentials.Deficiency of RIM1 decreases presynaptic Ca2+ channel density. RIM proteins are involved in neurotransmitter release and contribute to long- and short-term synaptic plasticity.

ID gène: 84556

UniProt: Q9JIR4

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity