Stim2 anticorps (C-Term, Intracellular)

N° du produit ABIN7885544

Cet anticorps anti-Stim2 Polyclonal Lapin (ABIN7885544) détecte spécifiquement Stim2 dans WB, IHC, IF et IC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Stim2 anticorps (C-Term, Intracellular) (ABIN7885544)

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stim2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-Stim2 anticorps

Épitope: AA 583-597, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to STIM2

Homologie: Rat,mouse,bovine - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: SAEKQWEVPDTASEC, corresponding to amino acid residues 583-597 of human STIM2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237296)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Stim2

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Autre désignation: Stromal interaction molecule 2

Sujet:

Synonyms: Stromal interaction molecule 2

Description: Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become the focus of intense research.Recently, several key players of the store-operated complex have been identified: the Orai family consists of three members: Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor.3,4While STIM1 appears to be localized intracellularly at the ER membrane and at a much lower extent on the cell surface of several cell types, STIM2 appears to be localized solely at the ER membrane.5 The function of STIM2 still remains elusive and several models have been suggested.6-8

ID gène: 57620

UniProt: Q9P246

Pathways: TCR Signaling, BCR Signaling