SYN2 anticorps (Domain G, Intracellular)

N° du produit ABIN7885548

Cet anticorps Lapin Polyclonal détecte spécifiquement SYN2 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour SYN2 anticorps (Domain G, Intracellular) (ABIN7885548)

Antigène: SYN2 (Synapsin II (SYN2))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-SYN2 anticorps

Épitope: AA 438-450, Domain G, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Synapsin II

Homologie: Mouse - identical, human- 12,13 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)SGTLKEPDSSKTP, corresponding to amino acid residues 438-450 of rat Synapsin-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237311)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SYN2

Antigène: SYN2 (Synapsin II (SYN2))

Autre désignation: Synapsin-2

Sujet:

Synonyms: Synapsin-2

Description: Synapsins are a family of ten homologous neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Synapsins appear to be crucial determinants for the fine-tuning of synaptic transmission and for synaptic remodeling. This is particularly evident in several paradigms of short-term plasticity (STP), which are specifically affected by mutations or malfunctioning of synapsin proteins. Notably, knockout of synapsin-2 in mice causes fully generalized forebrain seizures from the age of 2 months1.All synapsins, including synapsin-2, are composed of a highly homologous N-terminal region, and a more variable C-terminus. The N-terminal homologous region can be divided in three domains, namely domain A, B and C, which, except for domain B, are highly conserved across isoforms and species. Domain A is contains the phosphorylation site for PKA and CaMKI. Domain B, rich in small amino acids, is considered as a linker region connecting domain A to domain C. Domain C is a large region of about 300 amino acids, containing both hydrophobic and highly charged sequences with the potential to assume α-helix and β-sheet conformations. It shows extensive homology amongst the various members of the family, and mediates the core functions of synapsins1.

ID gène: 29179

UniProt: Q63537