TACR2 anticorps (Intracellular, N-Term)

N° du produit ABIN7885567

L’anticorps anti-TACR2 Polyclonal Lapin est utilisé pour la détection de TACR2 dans des échantillons de Rat et Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour TACR2 anticorps (Intracellular, N-Term) (ABIN7885567)

Antigène: TACR2 (Tachykinin Receptor 2 (TACR2))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-TACR2 anticorps

Épitope: AA 351-367, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neurokinin 2 Receptor

Homologie: Mouse - identical, human - 13,17 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CHTKETLFMTGDMTHSE, corresponding to amino acid residues 351-367 of rat NK2 receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237373)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TACR2

Antigène: TACR2 (Tachykinin Receptor 2 (TACR2))

Autre désignation: NK2 receptor

Sujet:

Synonyms: NK2 receptor, Neurokinin A receptor, Tachykinin receptor 2, TACR2, Substance-K receptor, SKR

Description: Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides, which demonstrate quite a heterogeneity in their distribution, exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 (NK1) receptor preferentially binds Substance P, Neurokinin 2 (NK2) receptor to NKA, and Neurokinin 3 (NK3) receptor to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 receptor is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 receptor is widely expressed in neurons, endothelial cells, muscle and immune system cells. NK2 receptor is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 receptor on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.

ID gène: 25007

UniProt: P16610

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion