TMEM108 anticorps (Extracellular Loop)

N° du produit ABIN7885616

Cet anticorps anti-TMEM108 Polyclonal Lapin (ABIN7885616) détecte spécifiquement TMEM108 dans WB, FACS, IHC et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TMEM108 anticorps (Extracellular Loop) (ABIN7885616)

Antigène: TMEM108 (Transmembrane Protein 108 (TMEM108))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM108 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-TMEM108 anticorps

Épitope: AA 208-223, Extracellular Loop

Fonction: A Rabbit Polyclonal Antibody to TMEM108 (Extracellular)

Homologie: Rat,mouse - 15 out of 16 amino acid residues identical.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GQKRPLGKIFQIYKGN, corresponding to amino acid residues 208 - 223 of human TMEM108

Isotype: IgG

Information d'application

Indications d'application: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMEM108

Antigène: TMEM108 (Transmembrane Protein 108 (TMEM108))

Autre désignation: TMEM108

Sujet:

Synonyms: Transmembrane Protein 108, Retrolinkin, RTLN

Description:

TMEM108 (Transmembrane Protein 108) is a transmembrane protein originally identified as Retrolinkin, a protein involved in retrograde axon transport in the brain.1

TMEM108 is predominantly expressed in the brain where it has roles in neural connectivity and plasticity.

Indeed, TMEM108 has garnered attention in neuropsychiatric research due to its involvement in several cellular processes critical for proper brain function. A growing body of evidence links TMEM108 dysregulation to a range of neuropsychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder (MDD).2,3

TMEM108 plays a role in dendritic spine formation and synaptic transmission in neurons. Abnormalities in these processes can disrupt neural circuitry, which is a common feature in neuropsychiatric conditions. Disrupted synaptic connectivity has been implicated in the cognitive and behavioral symptoms observed in disorders such as schizophrenia.4,5

Beyond neurons, TMEM108 is expressed in oligodendrocytes and their precursors. Impaired oligodendrocyte function and myelin integrity can affect signal propagation along axons, potentially contributing to the white matter abnormalities frequently reported in psychiatric disorders. This dual role in both neuronal and glial cells positions TMEM108 as a key factor in maintaining overall brain network integrity.6

Given its multifaceted role in brain physiology, TMEM108 is being investigated as a potential biomarker for early diagnosis and prognosis in neuropsychiatric disorders. Understanding its function could also pave the way for developing targeted therapies aimed at restoring synaptic and myelin integrity.

ID gène: 66000

UniProt: Q6UXF1