GLYR1 anticorps (C-Term)

N° du produit ABIN7938142

Cet anticorps anti-GLYR1 Polyclonal Lapin (ABIN7938142) détecte spécifiquement GLYR1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GLYR1 anticorps (C-Term) (ABIN7938142)

Antigène: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLYR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GLYR1 anticorps

Épitope: C-Term

Fonction: GLYR1 antibody (pAb)

Purification: Affinity Purified

Immunogène: This antibody was raised against a peptide within the C-terminal region of human GLYR1.

Isotype: IgG

Information d'application

Indications d'application: WB*: 0.5 - 2 μg/mL *Note: Many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western blot.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris, 105 mM NaCl, 0.07 mM EDTA, 31 mM glycine, 30 % glycerol, and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur GLYR1

Antigène: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Autre désignation: GLYR1

Sujet:

Background_Plain: GLYR1 / NDF (nucleosome-destabilizing factor) that is recruited to gene bodies during transcriptional activation and facilitates Pol II transcription through nucleosomes, where it is proposed to ""unzip"" chromatin during transcription, pushing the polymerase past pause points. It was discovered as a factor that allows p300 to acetylate Histone H3K56, which is normally an inaccessible residue for this modification. GLYR1 is shown to associate with a subset of highly transcribed genes tending to have longer mRNAs rather than shorter, and is also at a significant subset of loci containing the Histone H3K36me3. GLYR1 is expressed at high levels in most tissue types, including stem cells, and has been found to be overexpressed in breast cancer.

Aliases: Glyoxylate Reductase 1 Homolog, HIBDL, HNDF, NDF

Poids moléculaire: 65 kDa

NCBI Accession: NP_115958