HNRNPC anticorps

N° du produit ABIN7938264

L’anticorps anti-HNRNPC Polyclonal Lapin est utilisé pour la détection de HNRNPC dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour HNRNPC anticorps (ABIN7938264)

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPC est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HNRNPC anticorps

Fonction: HNRNPC antibody (pAb)

Purification: Protein A Chromatography

Immunogène: Peptide containing a sequence fragment corresponding to human heterogeneous nuclear ribonucleoprotein C.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5 - 2 μg/mL For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.05 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur HNRNPC

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Autre désignation: HNRNPC

Sujet:

Background_Plain: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) is a member of the subfamily nuclear ribonucleoproteins (hnRNPs) involved in pre-mRNA processing, mRNA metabolism, and transport. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene (C1 and C2). HNRNPC is a critical alternative splicing regulator that complexes with heterogeneous nuclear RNA (hnRNA) and plays an essential role in RNA maturation, stabilization, translocation, and posttranscriptional modification. Cellular homeostasis, among other cellular processes, is regulated by RNA alternative splicing. Alternative splicing disfunction contributes to many disorders, including cancer. The up regulation of HNRNPC expression has been tied to cancer progression and is thought to function by regulating RNA splicing, RNA expression, RNA stability, mRNA translation, m6A RNA methylation, and dsRNA induced interferon response.

Aliases: Heterogeneous Nuclear Ribonucleoprotein C, hnRNP C, HNRPC

Poids moléculaire: 37 kDa

UniProt: P07910