KDM5B anticorps

N° du produit ABIN7938291

Cet anticorps anti-KDM5B Polyclonal Lapin (ABIN7938291) détecte spécifiquement KDM5B dans ChIP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour KDM5B anticorps (ABIN7938291)

Antigène: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM5B est non-conjugé

Application: Chromatin Immunoprecipitation (ChIP)

Détail du produit anti-KDM5B anticorps

Fonction: JARID1B / KDM5B antibody (pAb)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against a human peptide belonging to demethyase JARID1B.

Isotype: IgG

Information d'application

Indications d'application: ChIP-Seq: 10 µL each

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, 30 % glycerol, 0.035 % Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur KDM5B

Antigène: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Autre désignation: JARID1B

Sujet:

Background_Plain: Lysine (K)-specific demethylase 5B (KDM5B), also known as Jumonji, AT rich interactive domain 1B (JARID1B), is a histone demethylase that specifically demethylates lysine 4 of histone H3 (H3K4), thereby playing a central role in defining the histone code. KDM5B demethylates trimethylated, dimethylated and monomethylated H3K4. It does not demethylate histone H3K9 or H3K27. KDM5B functions as a transcriptional corepressor for FOXG1B and PAX9. KDM5B induces the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, it may act as a tumor suppressor for melanoma.

Aliases: Lysine Demethylase 5B, lysine (K)-specific demethylase 5B

Poids moléculaire: 180 kDa

NCBI Accession: NP_006609

Pathways: L'effet Warburg