Recombinant TARDBP anticorps (C-Term)

N° du produit ABIN7938519

Cet anticorps anti-TARDBP Monoclonal Lapin (Clone 5D17) (ABIN7938519) détecte spécifiquement TARDBP dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant TARDBP anticorps (C-Term) (ABIN7938519)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 5D17

Détail du produit anti-TARDBP anticorps

Épitope: C-Term

Fonction: TARDBP (C-terminal) (rAb), 100 μg (Clone 5D17)

Purification: Protein A Chromatography

Immunogène: This information is proprietary to Active Motif and/or its suppliers.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:5000-1:50000 dilution IHC: 1:1000-1:4000 dilution

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet:

Background_Plain: TARDBP (TAR DNA-binding protein 43) also known as ALS10 and TDP-43. TARDBP is a RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. In addition, TARDBP also has a variety of biological functions, such as plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts, regulates also mRNA stability, participates also in the normal skeletal muscle formation and regeneration, negatively regulates the expression of CDK6 and regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.

Aliases: TAR DNA-binding protein 43, ALS10, TDP-43

Poids moléculaire: 43 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion