Annexin a1 anticorps (AA 2-346) (PE)

N° du produit ABIN7968836

Cet anticorps anti-Annexin a1 Monoclonal Souris conjugué à PE (Clone 6B7F8) (ABIN7968836) détecte spécifiquement Annexin a1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Annexin a1 anticorps (AA 2-346) (PE) (ABIN7968836)

Antigène: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Annexin a1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 6B7F8

Détail du produit anti-Annexin a1 anticorps (PE)

Épitope: AA 2-346

Fonction: Anti-Annexin A1/ANXA1 Antibody (monoclonal, 6B7F8) PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human Annexin A1 shares 88%,89% amino acid (aa) sequence identity with mouse,rat Annexin A1,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Annexin A1 recombinant protein (Position: A2-N346). Human Annexin A1 shares 88% and 89% amino acid (aa) sequence identity with mouse and rat Annexin A1, respectively.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Annexin a1

Antigène: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Autre désignation: ANXA1

Sujet:

Background: ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

Gene Full Name: annexin A1

ID gène: 301

UniProt: P04083

Pathways: Hormone Transport