AANAT anticorps (AA 24-205) (HRP)

N° du produit ABIN7969890

Cet anticorps Lapin Polyclonal détecte spécifiquement AANAT dans ELISA, WB et IHC. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour AANAT anticorps (AA 24-205) (HRP) (ABIN7969890)

Antigène: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AANAT est conjugé à/à la HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-AANAT anticorps (HRP)

Épitope: AA 24-205

Fonction: Anti-Aanat Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Aanat recombinant protein (Position: C24-C205).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur AANAT

Antigène: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Autre désignation: Aanat

Sujet:

Background: Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.

Gene Full Name: arylalkylamine N-acetyltransferase

ID gène: 11298

UniProt: O88816

Pathways: Photoperiodism