ATR anticorps (AA 730-1303) (Biotin)

N° du produit ABIN7971504

Cet anticorps Lapin Polyclonal détecte spécifiquement ATR dans ELISA, IHC et WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ATR anticorps (AA 730-1303) (Biotin) (ABIN7971504)

Antigène: ATR (ATR serine/threonine kinase (ATR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-ATR anticorps (Biotin)

Épitope: AA 730-1303

Fonction: Anti-ATR Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ATR recombinant protein (Position: E730-A1303).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR

Sujet:

Background: Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Gene Full Name: ATR checkpoint kinase

ID gène: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus