AXIN2 anticorps (AA 614-843) (APC)

N° du produit ABIN7971721

L’anticorps anti-AXIN2 Polyclonal Lapin est utilisé pour la détection de AXIN2 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour AXIN2 anticorps (AA 614-843) (APC) (ABIN7971721)

Antigène: AXIN2 (Axin 2 (AXIN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXIN2 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-AXIN2 anticorps (APC)

Épitope: AA 614-843

Fonction: Anti-Axin 2/AXIN2 Antibody APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Axin 2/AXIN2 recombinant protein (Position: D614-D843).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur AXIN2

Antigène: AXIN2 (Axin 2 (AXIN2))

Autre désignation: AXIN2

Sujet:

Background: Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Gene Full Name: axin 2

ID gène: 8313

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling