BIM anticorps (AA 18-186) (Fluoro594)

N° du produit ABIN7972468

L’anticorps anti-BIM Polyclonal Lapin est utilisé pour la détection de BIM dans des échantillons de Souris. Il a été validé pour FACS.

Aperçu rapide pour BIM anticorps (AA 18-186) (Fluoro594) (ABIN7972468)

Antigène: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIM est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-BIM anticorps (Fluoro594)

Épitope: AA 18-186

Fonction: Anti-Bim/Bcl2l11 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Mouse Bcl2l11 shares 86.7%,98.8% amino acid (aa) sequence identity with human,rat Bcl2l11,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Bim/Bcl2l11 recombinant protein (Position: Q18-R186). Mouse Bcl2l11 shares 86.7% and 98.8% amino acid (aa) sequence identity with human and rat Bcl2l11, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur BIM

Antigène: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Autre désignation: Bcl2l11

Sujet:

Background: Bcl-2-like protein 11, commonly called BIM (Bcl-2?Interacting?Mediator of cell death), is a?protein?that in humans is encoded by the?BCL2L11?gene. BCL2 is a prototypic mammalian regulator of cell death. Certain members of the BCL2 family inhibit apoptosis, while other members facilitate this physiologic process of cell death. By screening a cDNA expression library using recombinant BCL2 as bait, O'Connor et al. isolated a small novel protein, which they referred to as BIM, with a 9-amino acid BH3 motif shared by most BCL2 homologs. BIM provokes apoptosis, and the BH3 region is required for BCL2 binding and for most of its cytotoxicity.

Gene Full Name: BCL2 like 11

ID gène: 12125

UniProt: O54918

Pathways: Signalisation PI3K-Akt, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity