BRCC3 anticorps (AA 10-276) (Fluoro488)

N° du produit ABIN7973160

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCC3 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BRCC3 anticorps (AA 10-276) (Fluoro488) (ABIN7973160)

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-BRCC3 anticorps (Fluoro488)

Épitope: AA 10-276

Fonction: Anti-BRCC36/BRCC3 Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human BRCC36/BRCC3 recombinant protein (Position: Q10-M276).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC3

Sujet:

Background: Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Gene Full Name: BRCA1/BRCA2-containing complex subunit 3

ID gène: 79184

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus