C6orf150 anticorps (AA 208-522) (FITC)

N° du produit ABIN7980130

L’anticorps anti-C6orf150 Polyclonal Lapin est utilisé pour la détection de C6orf150 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour C6orf150 anticorps (AA 208-522) (FITC) (ABIN7980130)

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C6orf150 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-C6orf150 anticorps (FITC)

Épitope: AA 208-522

Fonction: Anti-CGAS Antibody FITC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CGAS recombinant protein (Position: L208-F522).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur C6orf150

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Autre désignation: CGAS

Sujet:

Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Gene Full Name: cyclic GMP-AMP synthase

ID gène: 115004

UniProt: Q8N884

Pathways: Activation of Innate immune Response