C6orf150 anticorps (AA 352-504)

N° du produit ABIN7980136

L’anticorps anti-C6orf150 Polyclonal Lapin est utilisé pour la détection de C6orf150 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC, ELISA, ICC et IF.

Aperçu rapide pour C6orf150 anticorps (AA 352-504) (ABIN7980136)

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C6orf150 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-C6orf150 anticorps

Épitope: AA 352-504

Fonction: Anti-cGAS Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-cGAS Antibody. Tested in WB, IHC, ICC/IF, ELISA. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human cGAS recombinant protein (Position: A352-F504).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur C6orf150

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Autre désignation: Cgas

Sujet:

Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Gene Full Name: cyclic GMP-AMP synthase

Poids moléculaire: 58-65 kDa

ID gène: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response