C6orf150 anticorps (AA 352-504) (APC)

N° du produit ABIN7980144

Cet anticorps Lapin Polyclonal détecte spécifiquement C6orf150 dans FACS. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour C6orf150 anticorps (AA 352-504) (APC) (ABIN7980144)

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C6orf150 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-C6orf150 anticorps (APC)

Épitope: AA 352-504

Fonction: Anti-cGAS Antibody APC Conjugated

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human cGAS recombinant protein (Position: A352-F504).

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur C6orf150

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Autre désignation: Cgas

Sujet:

Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Gene Full Name: cyclic GMP-AMP synthase

ID gène: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response