CRTC1 anticorps (C-Term) (Fluoro594)

N° du produit ABIN7981793

Cet anticorps anti-CRTC1 Polyclonal Lapin conjugué à Fluoro594 (ABIN7981793) détecte spécifiquement CRTC1 dans FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CRTC1 anticorps (C-Term) (Fluoro594) (ABIN7981793)

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRTC1 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-CRTC1 anticorps (Fluoro594)

Épitope: C-Term

Fonction: Anti-TORC1/CRTC1 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human TORC1/CRTC1, which shares 93.5% amino acid (aa) sequence identity with both mouse and rat TORC1/CRTC1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CRTC1

Antigène: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Autre désignation: CRTC1

Sujet:

Background: CRTC1 (CREB-Regulated Transcription Coactivator 1), also known as MECT1, TORC1 or KIAA0616, is a protein that in humans is encoded by the CRTC1 gene. By sequence analysis, Tonon et al. (2003) mapped the CRTC1 gene to chromosome 19p13. Kovacs et al. (2007) found that Torc1 was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Mair et al. (2011) demonstrated that CRTC1 is a AMPK target, and interacts with the CREB homolog-1 (CRH1) transcription factor in vivo. The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms.

Gene Full Name: CREB regulated transcription coactivator 1

ID gène: 23373

UniProt: Q6UUV9