Dynactin 1 anticorps (AA 1042-1278)

N° du produit ABIN7986532

L’anticorps anti-Dynactin 1 Polyclonal Lapin est utilisé pour la détection de Dynactin 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC, IF, FACS et ICC.

Aperçu rapide pour Dynactin 1 anticorps (AA 1042-1278) (ABIN7986532)

Antigène: Dynactin 1 (DCTN1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynactin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Classe de qualité: Carrier-free

Détail du produit anti-Dynactin 1 anticorps

Épitope: AA 1042-1278

Fonction: Anti-DCTN1/p150-glued Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-DCTN1/p150-glued Antibody. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DCTN1/p150-glued recombinant protein (Position: K1042-S1278).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Dynactin 1

Antigène: Dynactin 1 (DCTN1)

Autre désignation: DCTN1

Sujet:

Background: Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene. This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains ly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene Full Name: dynactin subunit 1

Poids moléculaire: 150 kDa

ID gène: 1639

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling