E2F2 anticorps (C-Term) (Fluoro594)

N° du produit ABIN7986793

L’anticorps anti-E2F2 Polyclonal Lapin est utilisé pour la détection de E2F2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour E2F2 anticorps (C-Term) (Fluoro594) (ABIN7986793)

Antigène: E2F2 (E2F Transcription Factor 2 (E2F2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F2 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-E2F2 anticorps (Fluoro594)

Épitope: C-Term

Fonction: Anti-Transcription factor E2F2 E2F2 Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human E2F2, identical to the related mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur E2F2

Antigène: E2F2 (E2F Transcription Factor 2 (E2F2))

Autre désignation: E2F2

Sujet:

Background: E2F2 (E2F transcription factor 2) also called E2F-2, is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F2 gene is mapped to 1p36 by fluorescence in situ hybridization. Electrophoretic mobility shift assays revealed the specific binding of E2F2 to ECE1b promoter sequences containing either allele of the C-338A polymorphism, with the -338A allele being associated with an increased affinity to E2F2 compared with -338C. The ability of Myc to induce S phase was impaired in the absence of either E2f2 or E2f3 but not E2f1 or E2f4. In contrast, the ability of Myc to induce apoptosis was markedly reduced in cells deleted for E2f1 but not E2f2 or E2f3.

Gene Full Name: E2F transcription factor 2

Sequence Similarities: Belongs to the E2F/DP family.

ID gène: 1870

UniProt: Q14209

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication