E2F4 anticorps (N-Term) (PE)

N° du produit ABIN7986808

L’anticorps anti-E2F4 Polyclonal Lapin est utilisé pour la détection de E2F4 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour E2F4 anticorps (N-Term) (PE) (ABIN7986808)

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F4 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-E2F4 anticorps (PE)

Épitope: N-Term

Fonction: Anti-E2F4 Antibody PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human E2F4, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur E2F4

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Autre désignation: E2F4

Sujet:

Background: Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. This gene is mapped to 16q22.1. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. Additionally, it plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Gene Full Name: E2F transcription factor 4

ID gène: 1874

UniProt: Q16254

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size