FBXW7 anticorps (AA 151-591) (Biotin)

N° du produit ABIN7989442

L’anticorps anti-FBXW7 Polyclonal Lapin est utilisé pour la détection de FBXW7 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour FBXW7 anticorps (AA 151-591) (Biotin) (ABIN7989442)

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW7 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-FBXW7 anticorps (Biotin)

Épitope: AA 151-591

Fonction: Anti-FBXW7 Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human FBXW7 shares 99.3%,98.9% amino acid (aa) sequence identity with mouse,rat FBXW7,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human FBXW7 recombinant protein (Position: D151-D591). Human FBXW7 shares 99.3% and 98.9% amino acid (aa) sequence identity with mouse and rat FBXW7, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: FBXW7

Sujet:

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: F-box and WD repeat domain containing 7

ID gène: 55294

UniProt: Q969H0

Pathways: Signalisation Notch, EGFR Signaling Pathway