FGF21 anticorps (AA 29-209) (APC)

N° du produit ABIN7990561

L’anticorps anti-FGF21 Polyclonal Lapin est utilisé pour la détection de FGF21 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour FGF21 anticorps (AA 29-209) (APC) (ABIN7990561)

Antigène: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGF21 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-FGF21 anticorps (APC)

Épitope: AA 29-209

Fonction: Anti-FGF21 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human FGF21 recombinant protein (Position: H29-S209).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur FGF21

Antigène: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Autre désignation: FGF21

Sujet:

Background: FGF21 (Fibroblast growth factor 21) is a protein that in humans is encoded by the FGF21 gene, which is also a member of the fibroblast growth factor (FGF) family. The FGF21 gene is mapped on 19q13.33. Using RT-PCR, Fgf21 was expressed in several types of adipose tissue in mice, including subcutaneous and epididymal fat pads and brown adipose tissue. The level of Fgf21 expression in adipose tissue was comparable to that in liver. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Changes in Fgf21 expression due to suckling or nutritional manipulations were associated with changes in circulating free fatty acid and ketone body levels. In differentiated mouse brown adipocytes in culture, Fgf21 treatment increased the expression of thermogenic genes, caused higher total and uncoupled respiration, and enhanced glucose oxidation.

Gene Full Name: fibroblast growth factor 21

ID gène: 26291

UniProt: Q9NSA1

Pathways: Signalisation RTK