FOXL2 anticorps (C-Term) (Biotin)

N° du produit ABIN7991458

L’anticorps anti-FOXL2 Polyclonal Lapin est utilisé pour la détection de FOXL2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour FOXL2 anticorps (C-Term) (Biotin) (ABIN7991458)

Antigène: FOXL2 (Forkhead Box L2 (FOXL2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXL2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FOXL2 anticorps (Biotin)

Épitope: C-Term

Fonction: Anti-FOXL2 Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: identical to the related mouse sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human FOXL2, identical to the related mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FOXL2

Antigène: FOXL2 (Forkhead Box L2 (FOXL2))

Autre désignation: FOXL2

Sujet:

Background: The forkhead transcription factor gene, FOXL2 located in blepharophimosis-ptosis-epicanthus inversus syndrome(BPES) critical region on chromosome 3q23. Consistent with an involvement in BPES, FOXL2 is selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles, in adult humans, it appears predominantly in the ovary. FOXL2 haploinsufficiency may cause BPES types I and II by the effect of a null allele and a hypomorphic allele, respectively. Furthermore, in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect. FOXL2 mutations can also cause gonadal dysgenesis or premature ovarian failure(POF) in women, as well as eyelid/forehead dysmorphology in both sexes.

Gene Full Name: forkhead box L2

ID gène: 668

UniProt: P58012

Pathways: Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity