GFRA1 anticorps (AA 25-227) (Fluoro488)

N° du produit ABIN7993017

Cet anticorps Lapin Polyclonal détecte spécifiquement GFRA1 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GFRA1 anticorps (AA 25-227) (Fluoro488) (ABIN7993017)

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA1 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-GFRA1 anticorps (Fluoro488)

Épitope: AA 25-227

Fonction: Anti-GDNF Receptor alpha 1/GFRA1 Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse,rat GFRA1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur GFRA1

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Autre désignation: GFRA1

Sujet:

Background: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Gene Full Name: GDNF family receptor alpha 1

Sequence Similarities: Belongs to the glutamate--cysteine ligase type 3 family.

ID gène: 14585

UniProt: P56159