GDNF anticorps (Middle Region) (PE)

N° du produit ABIN7993287

Cet anticorps Lapin Polyclonal détecte spécifiquement GDNF dans FACS. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour GDNF anticorps (Middle Region) (PE) (ABIN7993287)

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDNF est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-GDNF anticorps (PE)

Épitope: Middle Region

Fonction: Anti-GDNF Antibody PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse sequence by three amino acids,rat sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of < a href=https://www.bosterbio.com/human-gdnf-picokine-trade-elisa-kit-ek0362-boster.html style=color:#EA8D28>human GDNF, different from the related mouse sequence by three amino acids and rat sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur GDNF

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Autre désignation: GDNF

Sujet:

Background: GDNF, Glial cell-derived neurotrophic factor, is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF is a founding member of the GDNF family of ligands (GFL). The GDNF gene is mapped to human chromosome 5p13.1-p12 by fluorescence in situ hybridization (FISH). This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosisof motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene.

Gene Full Name: glial cell derived neurotrophic factor

Sequence Similarities: Belongs to the TGF-beta family. GDNF subfamily.

ID gène: 2668

UniProt: P39905

Pathways: Signalisation RTK, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration