GLUD1 / GLUD2 (AA 54-553) anticorps (HRP)

N° du produit ABIN7993582

L’anticorps anti-GLUD1 / GLUD2 Polyclonal Lapin est utilisé pour la détection de GLUD1 / GLUD2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB et IHC.

Aperçu rapide pour GLUD1 / GLUD2 (AA 54-553) anticorps (HRP) (ABIN7993582)

Antigène: GLUD1 / GLUD2

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit

Épitope: AA 54-553

Fonction: Anti-GLUD1/2 Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GLUD1/2 recombinant protein (Position: S54-A553).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détail du antigène

Antigène: GLUD1 / GLUD2

Autre désignation: GLUD1/2

Sujet:

Background: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

Gene Full Name: glutamate dehydrogenase 1/2

ID gène: 2746, 2747

UniProt: P00367