HNF4A anticorps (AA 164-474)

N° du produit ABIN7997198

Cet anticorps anti-HNF4A Monoclonal Souris (Clone 6C8E9) (ABIN7997198) détecte spécifiquement HNF4A dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour HNF4A anticorps (AA 164-474) (ABIN7997198)

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HNF4A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Clone: 6C8E9

Détail du produit anti-HNF4A anticorps

Épitope: AA 164-474

Fonction: Anti-HNF-4-alpha Antibody (monoclonal, 6C8E9)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human HNF-4-alpha shares 95%,96% amino acid (aa) sequence identity with mouse,rat HNF-4-alpha,respectively.

Attributs du produit: Anti-HNF-4-alpha Antibody.(monoclonal, 6C8E9)-2. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human HNF-4-alpha recombinant protein (Position: Q164-I474). Human HNF-4-alpha shares 95% and 96% amino acid (aa) sequence identity with mouse and rat HNF-4-alpha, respectively.

Isotype: IgG2a

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur HNF4A

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Autre désignation: HNF4A

Sujet:

Background: Hepatocyte nuclear factor 4 alpha (HNF4A), also known as NR2A1, is a nuclear receptor that in humans is encoded by the HNF4A gene. It is mapped to 20q13.12. HNF4A is a nuclear transcription factor that binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene plays a role in development of the liver, kidney, and intestines. HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4. This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Oestrogen as-well as prolonging the half-life of Testosterone.

Gene Full Name: hepatocyte nuclear factor 4 alpha

Poids moléculaire: 53 kDa

ID gène: 3172

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process