ITGB3BP anticorps (AA 1-177) (APC)

N° du produit ABIN8000568

L’anticorps anti-ITGB3BP Polyclonal Lapin est utilisé pour la détection de ITGB3BP dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour ITGB3BP anticorps (AA 1-177) (APC) (ABIN8000568)

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGB3BP est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-ITGB3BP anticorps (APC)

Épitope: AA 1-177

Fonction: Anti-Centromere protein R/ITGB3BP Antibody APC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human ITGB3BP shares 94.4%,59.8% amino acid (aa) sequence identity with mouse,rat ITGB3BP,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Centromere protein R/ITGB3BP recombinant protein (Position: M1-N177). Human ITGB3BP shares 94.4% and 59.8% amino acid (aa) sequence identity with mouse and rat ITGB3BP, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ITGB3BP

Antigène: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Autre désignation: ITGB3BP

Sujet:

Background: Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

Gene Full Name: integrin subunit beta 3 binding protein

ID gène: 23421

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway