LARP1 anticorps (AA 123-401) (APC)

N° du produit ABIN8004870

L’anticorps anti-LARP1 Polyclonal Lapin est utilisé pour la détection de LARP1 dans des échantillons de Humain et Souris. Il a été validé pour FACS.

Aperçu rapide pour LARP1 anticorps (AA 123-401) (APC) (ABIN8004870)

Antigène: LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LARP1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-LARP1 anticorps (APC)

Épitope: AA 123-401

Fonction: Anti-LARP1 Antibody APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human LARP1 recombinant protein (Position: K123-E401).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur LARP1

Antigène: LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))

Autre désignation: LARP1

Sujet:

Background: La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. La-related protein 1 (LARP1) is a ubiquitously expressed RNA binding protein that promotes both global and specific mRNA translation in cells. LARP1 belongs to the La-related protein family and contains two RNA binding domains, a La motif (LAM), and a neighboring RNA recognition motif-like (RRM-L) domain. Research studies indicate that LARP1 acts downstream of mTORC1 to facilitate cell proliferation and growth by promoting global mRNA translation and translation of mRNAs containing a 5'Terminal Oligo-Pyrimidine (5'TOP) motif, which code for translational machinery components. At the molecular level, LARP1 associates with 5'TOP mRNAs and multiple translation machinery components to positively regulate translation. Additional studies show that LARP1 expression is upregulated in hepatocellular carcinoma (HCC) patients and that high LARP1 expression in HCC negatively correlates with survival rate.

Gene Full Name: La ribonucleoprotein 1, translational regulator

ID gène: 23367

UniProt: Q6PKG0

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2