MTDH anticorps (AA 101-270) (PE)

N° du produit ABIN8009317

Cet anticorps anti-MTDH Monoclonal Souris conjugué à PE (Clone 2E5G3) (ABIN8009317) détecte spécifiquement MTDH dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MTDH anticorps (AA 101-270) (PE) (ABIN8009317)

Antigène: MTDH (Metadherin (MTDH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MTDH est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 2E5G3

Détail du produit anti-MTDH anticorps (PE)

Épitope: AA 101-270

Fonction: Anti-LYRIC Antibody (monoclonal, 2E5G3) PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse,rat LYRIC.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human LYRIC recombinant protein (Position: D101-Q270). Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse and rat LYRIC.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MTDH

Antigène: MTDH (Metadherin (MTDH))

Autre désignation: MTDH

Sujet:

Background: MTDH (Metadherin), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

Gene Full Name: metadherin

ID gène: 92140

UniProt: Q86UE4

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization