MSH2 anticorps (AA 337-583) (Fluoro647)

N° du produit ABIN8010606

L’anticorps anti-MSH2 Monoclonal Souris est utilisé pour la détection de MSH2 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour MSH2 anticorps (AA 337-583) (Fluoro647) (ABIN8010606)

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH2 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Clone: 6B4F7

Détail du produit anti-MSH2 anticorps (Fluoro647)

Épitope: AA 337-583

Fonction: Anti-MSH2 Antibody (monoclonal, 6B4F7) Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human MSH2 shares 94%,93% amino acid (aa) sequence identity with mouse,rat MSH2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MSH2

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Autre désignation: MSH2

Sujet:

Background: DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms aheterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.

Gene Full Name: mutS homolog 2

ID gène: 4436

UniProt: P43246

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response