Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) (AA 10-459) anticorps

N° du produit ABIN8010805

Cet anticorps anti-Mitochondrially Encoded NADH Dehydrogenase 4 Polyclonal Lapin (ABIN8010805) détecte spécifiquement Mitochondrially Encoded NADH Dehydrogenase 4 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) (AA 10-459) anticorps (ABIN8010805)

Antigène: Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Détail du produit

Épitope: AA 10-459

Fonction: Anti-MT-ND4 Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-MT-ND4 Antibody. Tested in ELISA, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MT-ND4 recombinant protein (Position: M10-S459).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4)

Autre désignation: MT-ND4

Sujet:

Background: NADH-ubiquinone oxidoreductase chain 4 is a protein that in humans is encoded by the mitochondrial gene MT-ND4. MT-ND4 is a subunit of the respiratory chain Complex I that is believed to belong to the minimal assembly of core proteins required to catalyze NADH dehydrogenation and electron transfer to ubiquinone (coenzyme Q10). Initially, NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix.

Gene Full Name: NADH dehydrogenase subunit 4

Poids moléculaire: 36 kDa

ID gène: 4538

UniProt: P03905