MUTYH anticorps (AA 1-559) (APC)

N° du produit ABIN8012232

L’anticorps anti-MUTYH Polyclonal Lapin est utilisé pour la détection de MUTYH dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour MUTYH anticorps (AA 1-559) (APC) (ABIN8012232)

Antigène: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUTYH est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-MUTYH anticorps (APC)

Épitope: AA 1-559

Fonction: Anti-MUTYH Antibody APC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human IFFO1 recombinant protein (Position: M1-R559). Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MUTYH

Antigène: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Autre désignation: MUTYH

Sujet:

Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: mutY DNA glycosylase

ID gène: 4595

UniProt: Q9UIF7

Pathways: Réparation de l'ADN