MAX anticorps (AA 30-106) (Fluoro594)

N° du produit ABIN8012273

Cet anticorps Lapin Polyclonal détecte spécifiquement MAX dans FACS. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour MAX anticorps (AA 30-106) (Fluoro594) (ABIN8012273)

Antigène: MAX (MYC Associated Factor X (MAX))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAX est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-MAX anticorps (Fluoro594)

Épitope: AA 30-106

Fonction: Anti-MAX Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human MAX recombinant protein (Position: A30-R106).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MAX

Antigène: MAX (MYC Associated Factor X (MAX))

Autre désignation: MAX

Sujet:

Background: MAX (Max protein), also called Myc-associated factor x, is the most conserved dimerization component of the MYC-MAX-MXD1 network of basic helix-loop-helix leucine zipper (bHLHZ) transcription factors that regulate cell proliferation, differentiation, and apoptosis. The conservation of the MAX sequence is particularly high in the bHLHZ domain, which is involved in protein-protein interactions and DNA binding. The MAX gene is located on chromosome 14q23 by fluorescence in situ chromosomal hybridization. Both quasisymmetric heterodimers resemble the symmetric MAX homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these 3 evolutionarily related DNA-binding proteins. MAX acts as a classic tumor suppressor gene. Normal lymphocytes from patients showed absence of methylation of the MAX promoter and biallelic expression of MAX, which ruled out an imprinting-mediated effect on MAX expression. The ability of these cells to divide, differentiate, and apoptose in the absence of Max demonstrated for the first time that these processes can occur via Max- and possibly Myc-independent mechanisms.

Gene Full Name: MYC associated transcriptional regulator X

ID gène: 4149

UniProt: P61244

Pathways: Mitotic G1-G1/S Phases