MPL anticorps (AA 26-595) (FITC)

N° du produit ABIN8012516

Cet anticorps Lapin Polyclonal détecte spécifiquement MPL dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MPL anticorps (AA 26-595) (FITC) (ABIN8012516)

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPL est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-MPL anticorps (FITC)

Épitope: AA 26-595

Fonction: Anti-TPOR/MPL Antibody FITC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human TPOR,MPL shares 79.6% amino acid (aa) sequence identity with mouse TPOR,MPL.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TPOR/MPL recombinant protein (Position: Q26-Q595). Human TPOR/MPL shares 79.6% amino acid (aa) sequence identity with mouse TPOR/MPL.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MPL

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: MPL

Sujet:

Background: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Gene Full Name: MPL proto-oncogene, thrombopoietin receptor

ID gène: 352

UniProt: P40238

Pathways: Signalistation JAK/STAT