Oncostatin M anticorps (AA 26-220)

N° du produit ABIN8018058

L’anticorps anti-Oncostatin M Polyclonal Lapin est utilisé pour la détection de Oncostatin M dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour Oncostatin M anticorps (AA 26-220) (ABIN8018058)

Antigène: Oncostatin M (OSM)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Oncostatin M anticorps

Épitope: AA 26-220

Fonction: Anti-Oncostatin M/OSM Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human Oncostatin M recombinant protein (Position: A26-R220). Human Oncostatin M shares 47.1%,47.6% amino acid (aa) sequence identity with mouse,rat Oncostatin M,respectively.

Attributs du produit: Anti-Oncostatin M/OSM Antibody. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Oncostatin M recombinant protein (Position: A26-R220). Human Oncostatin M shares 47.1% and 47.6% amino acid (aa) sequence identity with mouse and rat Oncostatin M, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -Western blot, 0.1-0.5 μg/mL, Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Oncostatin M

Antigène: Oncostatin M (OSM)

Autre désignation: OSM

Sujet:

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Gene Full Name: oncostatin M

Poids moléculaire: 40 kDa

ID gène: 5008

UniProt: P13725

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion