Oncostatin M anticorps (AA 55-158) (Fluoro647)

N° du produit ABIN8018090

Cet anticorps Lapin Polyclonal détecte spécifiquement Oncostatin M dans FACS. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour Oncostatin M anticorps (AA 55-158) (Fluoro647) (ABIN8018090)

Antigène: Oncostatin M (OSM)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-Oncostatin M anticorps (Fluoro647)

Épitope: AA 55-158

Fonction: Anti-Osm Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Rat Osm shares 46%,71.2% amino acid (aa) sequence identity with human,mouse Osm,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived rat Osm recombinant protein (Position: E55-D158). Rat Osm shares 46% and 71.2% amino acid (aa) sequence identity with human and mouse Osm, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Oncostatin M

Antigène: Oncostatin M (OSM)

Autre désignation: Osm

Sujet:

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Gene Full Name: oncostatin M

ID gène: 289747

UniProt: Q65Z15

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion