Oncostatin M Receptor anticorps (AA 673-968) (Cy3)

N° du produit ABIN8018104

Cet anticorps anti-Oncostatin M Receptor Polyclonal Lapin conjugué à Cy3 (ABIN8018104) détecte spécifiquement Oncostatin M Receptor dans FACS. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Oncostatin M Receptor anticorps (AA 673-968) (Cy3) (ABIN8018104)

Antigène: Oncostatin M Receptor (OSMR)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M Receptor est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-Oncostatin M Receptor anticorps (Cy3)

Épitope: AA 673-968

Fonction: Anti-Osmr Antibody Cy3 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Mouse Osmr shares 57.7%,86.9% amino acid (aa) sequence identity with human,rat Osmr,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968). Mouse Osmr shares 57.7% and 86.9% amino acid (aa) sequence identity with human and rat Osmr, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Oncostatin M Receptor

Antigène: Oncostatin M Receptor (OSMR)

Autre désignation: Osmr

Sujet:

Background: Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. Mosley et al. (1996) used degenerate PCR to clone a novel hematopoietin receptor which they called the oncostatin M-specific receptor beta subunit (OSMR-beta). Sequencing revealed that this gene encodes a 979-amino acid protein containing characteristic motifs of the hematopoietin receptor family.

Gene Full Name: oncostatin M receptor

ID gène: 18414

UniProt: O70458

Pathways: Signalistation JAK/STAT, Growth Factor Binding