Otoferlin anticorps (C-Term)

N° du produit ABIN8018611

Cet anticorps anti-Otoferlin Polyclonal Lapin (ABIN8018611) détecte spécifiquement Otoferlin dans IHC et WB. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Otoferlin anticorps (C-Term) (ABIN8018611)

Antigène: Otoferlin (OTOF)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Otoferlin est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-Otoferlin anticorps

Épitope: C-Term

Fonction: Anti-Otoferlin Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse,rat sequences.

Attributs du produit: Anti-Otoferlin Antibody. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Otoferlin, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Otoferlin

Antigène: Otoferlin (OTOF)

Autre désignation: OTOF

Sujet:

Background: Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.

Gene Full Name: otoferlin

Sequence Similarities: Belongs to the ferlin family.

Poids moléculaire: 227 kDa

ID gène: 9381

UniProt: Q9HC10

Pathways: Sensory Perception of Sound, Synaptic Vesicle Exocytosis