PIK3AP1 anticorps (AA 78-583) (HRP)

N° du produit ABIN8021852

Cet anticorps Lapin Polyclonal détecte spécifiquement PIK3AP1 dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PIK3AP1 anticorps (AA 78-583) (HRP) (ABIN8021852)

Antigène: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3AP1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PIK3AP1 anticorps (HRP)

Épitope: AA 78-583

Fonction: Anti-PIK3AP1 Antibody HRP Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PIK3AP1 shares 83.8% amino acid (aa) sequence identity with mouse PIK3AP1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PIK3AP1 recombinant protein (Position: H78-R583). Human PIK3AP1 shares 83.8% amino acid (aa) sequence identity with mouse PIK3AP1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PIK3AP1

Antigène: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Autre désignation: PIK3AP1

Sujet:

Background: Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene. BCAP (B cell adaptor for phosphoinositide 3-kinase (PI3K)), also known as PI3KAP1, participates in linking the B cell antigen receptor (BCR) with the PI3K pathway. Tyrosine phosphorylation of BCAP by BCR-associated protein tyrosine kinases, such as Syk and Btk, generates binding sites for the p85 subunit of PI3K, resulting in activation of the PI3K pathway. Human and mouse BCAP contain 3 YXXM SH2 binding motifs for interaction with PI3K. BCAP null mice have deficient immune function, with B cells that exhibit enhanced apoptosis.

Gene Full Name: phosphoinositide-3-kinase adaptor protein 1

ID gène: 118788

UniProt: Q6ZUJ8

Pathways: Activation of Innate immune Response, BCR Signaling, L'effet Warburg