PINX1 anticorps (N-Term) (APC)

N° du produit ABIN8022586

Cet anticorps anti-PINX1 Polyclonal Lapin conjugué à APC (ABIN8022586) détecte spécifiquement PINX1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PINX1 anticorps (N-Term) (APC) (ABIN8022586)

Antigène: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINX1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-PINX1 anticorps (APC)

Épitope: N-Term

Fonction: Anti-PINX1 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse,rat sequences by three amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1, different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PINX1

Antigène: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Autre désignation: PINX1

Sujet:

Background: PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

Gene Full Name: PIN2 (TERF1) interacting telomerase inhibitor 1

Sequence Similarities: Belongs to the PINX1 family.

ID gène: 54984

UniProt: Q96BK5