PTTG1 anticorps (C-Term) (Fluoro488)

N° du produit ABIN8022647

Cet anticorps Lapin Polyclonal détecte spécifiquement PTTG1 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PTTG1 anticorps (C-Term) (Fluoro488) (ABIN8022647)

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTTG1 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-PTTG1 anticorps (Fluoro488)

Épitope: C-Term

Fonction: Anti-Securin/PTTG1 Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by four amino acids,and from the related mouse sequence by five amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Securin, different from the related rat sequence by four amino acids, and from the related mouse sequence by five amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PTTG1

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Autre désignation: PTTG1

Sujet:

Background: Securin, also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene. PTTG1 gene is mapped to 5q33.3. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene Full Name: PTTG1 regulator of sister chromatid separation, securin

Sequence Similarities: Belongs to the securin family.

ID gène: 9232

UniProt: O95997