PTAFR anticorps (C-Term)

N° du produit ABIN8023144

Cet anticorps anti-PTAFR Polyclonal Lapin (ABIN8023144) détecte spécifiquement PTAFR dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PTAFR anticorps (C-Term) (ABIN8023144)

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTAFR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PTAFR anticorps

Épitope: C-Term

Fonction: Anti-PTAFR Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-PTAFR Antibody. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human PTAFR.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PTAFR

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Autre désignation: PTAFR

Sujet:

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Gene Full Name: platelet activating factor receptor

Poids moléculaire: 39 kDa

ID gène: 5724

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin