PLK1 anticorps (AA 86-430) (HRP)

N° du produit ABIN8023728

L’anticorps anti-PLK1 Monoclonal Souris est utilisé pour la détection de PLK1 dans des échantillons de Humain et Singe. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour PLK1 anticorps (AA 86-430) (HRP) (ABIN8023728)

Antigène: PLK1 (Polo-Like Kinase 1 (PLK1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PLK1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 6D11

Détail du produit anti-PLK1 anticorps (HRP)

Épitope: AA 86-430

Fonction: Anti-PLK1 Antibody (monoclonal, 6D11) HRP Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human PLK1 shares 95.4%,96.2% amino acid (aa) sequence identity with mouse,rat PLK1,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PLK1 recombinant protein (Position: K86-N430). Human PLK1 shares 95.4% and 96.2% amino acid (aa) sequence identity with mouse and rat PLK1, respectively.

Isotype: IgG2b

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PLK1

Antigène: PLK1 (Polo-Like Kinase 1 (PLK1))

Autre désignation: PLK1

Sujet:

Background: Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene. Plk1 is an early trigger for G2/M transition. It supports the functional maturation of the centrosome in late G2/early prophaseand establishment of the bipolar spindle. Also, Plk1 phosphorylates and activates cdc25C, a phosphatase that dephosphorylates and activates the cyclinB/cdc2 complex. Studies have shown that the loss of PLK1 expression can inducepro-apoptotic pathways and inhibit growth. Based on yeast and murine studies of meiosis, human PLK1 may also have a regulatory function in meiosis.

Gene Full Name: polo like kinase 1

ID gène: 5347

UniProt: P53350

Pathways: Cycle Cellulaire, M Phase