POLH anticorps (AA 157-361) (Fluoro488)

N° du produit ABIN8024134

Cet anticorps anti-POLH Polyclonal Lapin conjugué à Fluoro488 (ABIN8024134) détecte spécifiquement POLH dans FACS. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour POLH anticorps (AA 157-361) (Fluoro488) (ABIN8024134)

Antigène: POLH (Polymerase (DNA Directed), eta (POLH))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLH est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-POLH anticorps (Fluoro488)

Épitope: AA 157-361

Fonction: Anti-DNA polymerase eta/POLH Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human POLH recombinant protein (Position: A157-R361). Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur POLH

Antigène: POLH (Polymerase (DNA Directed), eta (POLH))

Autre désignation: POLH

Sujet:

Background: DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-ed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: DNA polymerase eta

ID gène: 5429

UniProt: Q9Y253

Pathways: Réparation de l'ADN