POU2AF1 anticorps (C-Term) (APC)

N° du produit ABIN8024823

L’anticorps anti-POU2AF1 Polyclonal Lapin est utilisé pour la détection de POU2AF1 dans des échantillons de Rat et Souris. Il a été validé pour FACS.

Aperçu rapide pour POU2AF1 anticorps (C-Term) (APC) (ABIN8024823)

Antigène: POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POU2AF1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-POU2AF1 anticorps (APC)

Épitope: C-Term

Fonction: Anti-BOB1/POU2AF1 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by one amino acid,and from human sequence by four amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of mouse BOB1, different from the related rat sequence by one amino acid, and from human sequence by four amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur POU2AF1

Antigène: POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

Autre désignation: POU2AF1

Sujet:

Background: POU2AF1 (POU domain class 2-associating factor 1), also known as OBF1, BOB1 and OCAB, is a protein that in humans is encoded by the POU2AF1 gene. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. Casellas et al. (2002) reported that OCAB is essential for V (D)J recombination of a subset of Ig-kappa genes. They showed that OCAB modulates recombination by ly enhancing Ig-kappa gene transcription in vivo. Siegel et al. (2006) suggested that, together with dysregulation of other OCAB target genes, altered regulation of SYK may help explain the magnitude of defects observed in B-cell development, including the pre-B1-to-pre-B2 transition, and immune responses in Ocab -/- mice.

Gene Full Name: POU domain, class 2, associating factor 1

ID gène: 18985

UniProt: Q64693