Prolactin Receptor anticorps (C-Term)

N° du produit ABIN8025771

L’anticorps anti-Prolactin Receptor Polyclonal Lapin est utilisé pour la détection de Prolactin Receptor dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Prolactin Receptor anticorps (C-Term) (ABIN8025771)

Antigène: Prolactin Receptor (PRLR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prolactin Receptor est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-Prolactin Receptor anticorps

Épitope: C-Term

Fonction: Anti-Prolactin Receptor/PRLR Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by eleven amino acids,and from the related rat sequence by fourteen amino acids.

Attributs du produit: Anti-Prolactin Receptor/PRLR Antibody. Tested in WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human PRLR, different from the related mouse sequence by eleven amino acids, and from the related rat sequence by fourteen amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Prolactin Receptor

Antigène: Prolactin Receptor (PRLR)

Autre désignation: PRLR

Sujet:

Background: PRLR (Prolactin Receptor) is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al. (1989, 1990) demonstrated that the prolactin receptor gene resides in the same chromosomal region as the growth hormone receptor gene, which has been mapped to 5p13-p12. Cunningham et al. (1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to the growth hormone receptor or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues (histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRL receptors but not GH receptors) are likely zinc-ion ligands.

Gene Full Name: prolactin receptor

Poids moléculaire: 90 kDa

ID gène: 5618

UniProt: P16471

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus